Bridgehead Modifications of Englerin A Reduce TRPC4 Activity and Intravenous Toxicity but not Cell Growth Inhibition

[Image: see text] Modifications at the bridgehead position of englerin A were made to explore the effects of variation at this site on the molecule for biological activity, as judged by the NCI 60 screen, in which englerin A is highly potent and selective for renal cancer cells. Replacement of the i...

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發表在:ACS Med Chem Lett
Main Authors: Wu, Zhenhua, Suppo, Jean-Simon, Tumova, Sarka, Strope, Jonathan, Bravo, Fernando, Moy, Melody, Weinstein, Ethan S., Peer, Cody J., Figg, William D., Chain, William J., Echavarren, Antonio M., Beech, David J., Beutler, John A.
格式: Artigo
語言:Inglês
出版: American Chemical Society 2020
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7488277/
https://ncbi.nlm.nih.gov/pubmed/32944138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00186
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