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Genetic and environmental determinants of human TCR repertoire diversity

T cell discrimination of self and non-self is the foundation of the adaptive immune response, and is orchestrated by the interaction between T cell receptors (TCRs) and their cognate ligands presented by major histocompatibility (MHC) molecules. However, the impact of host immunogenetic variation on...

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Bibliographische Detailangaben
Veröffentlicht in:Immun Ageing
Hauptverfasser: Krishna, Chirag, Chowell, Diego, Gönen, Mithat, Elhanati, Yuval, Chan, Timothy A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7487954/
https://ncbi.nlm.nih.gov/pubmed/32944053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12979-020-00195-9
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