Isogenic models of hypertrophic cardiomyopathy unveil differential phenotypes and mechanism-driven therapeutics

BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a prevalent and complex cardiovascular condition. Despite being strongly associated with genetic alterations, wide variation of disease penetrance, expressivity and hallmarks of progression complicate treatment. We aimed to characterize different huma...

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Опубликовано в: :J Mol Cell Cardiol
Главные авторы: Bhagwan, Jamie R., Mosqueira, Diogo, Chairez-Cantu, Karolina, Mannhardt, Ingra, Bodbin, Sara E., Bakar, Mine, Smith, James G.W., Denning, Chris
Формат: Artigo
Язык:Inglês
Опубликовано: Academic Press 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7487780/
https://ncbi.nlm.nih.gov/pubmed/32531470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2020.06.003
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