Mitochondrial DNA: Hotspot for Potential Gene Modifiers Regulating Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is a prevalent and untreatable cardiovascular disease with a highly complex clinical and genetic causation. HCM patients bearing similar sarcomeric mutations display variable clinical outcomes, implying the involvement of gene modifiers that regulate disease progres...

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Detalhes bibliográficos
Main Authors: Parisa K. Kargaran, Jared M. Evans, Sara E. Bodbin, James G. W. Smith, Timothy J. Nelson, Chris Denning, Diogo Mosqueira
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-07-01
Colecção:Journal of Clinical Medicine
Assuntos:
Hypertrophic cardiomyopathy
disease modeling
isogenic human pluripotent stem cell-derived cardiomyocytes
gene modifiers
mitochondrial DNA
haplogroups
Acesso em linha:https://www.mdpi.com/2077-0383/9/8/2349
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