Calcium modulates the domain flexibility and function of an α-actinin similar to the ancestral α-actinin

The actin cytoskeleton, a dynamic network of actin filaments and associated F-actin–binding proteins, is fundamentally important in eukaryotes. α-Actinins are major F-actin bundlers that are inhibited by Ca(2+) in nonmuscle cells. Here we report the mechanism of Ca(2+)-mediated regulation of Entamoe...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Pinotsis, Nikos, Zielinska, Karolina, Babuta, Mrigya, Arolas, Joan L., Kostan, Julius, Khan, Muhammad Bashir, Schreiner, Claudia, Salmazo, Anita, Ciccarelli, Luciano, Puchinger, Martin, Gkougkoulia, Eirini A., Ribeiro, Euripedes de Almeida, Marlovits, Thomas C., Bhattacharya, Alok, Djinovic-Carugo, Kristina
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7486759/
https://ncbi.nlm.nih.gov/pubmed/32848067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1917269117
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