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α-Actinin/titin interaction: A dynamic and mechanically stable cluster of bonds in the muscle Z-disk

Stable anchoring of titin within the muscle Z-disk is essential for preserving muscle integrity during passive stretching. One of the main candidates for anchoring titin in the Z-disk is the actin cross-linker α-actinin. The calmodulin-like domain of α-actinin binds to the Z-repeats of titin. Howeve...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Grison, Marco, Merkel, Ulrich, Kostan, Julius, Djinović-Carugo, Kristina, Rief, Matthias
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293040/
https://ncbi.nlm.nih.gov/pubmed/28096424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612681114
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