Order from disorder in the sarcomere: FATZ forms a fuzzy but tight complex and phase-separated condensates with α-actinin

In sarcomeres, α-actinin cross-links actin filaments and anchors them to the Z-disk. FATZ (filamin-, α-actinin-, and telethonin-binding protein of the Z-disk) proteins interact with α-actinin and other core Z-disk proteins, contributing to myofibril assembly and maintenance. Here, we report the firs...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Sponga, Antonio, Arolas, Joan L., Schwarz, Thomas C., Jeffries, Cy M., Rodriguez Chamorro, Ariadna, Kostan, Julius, Ghisleni, Andrea, Drepper, Friedel, Polyansky, Anton, De Almeida Ribeiro, Euripedes, Pedron, Miriam, Zawadzka-Kazimierczuk, Anna, Mlynek, Georg, Peterbauer, Thomas, Doto, Pierantonio, Schreiner, Claudia, Hollerl, Eneda, Mateos, Borja, Geist, Leonhard, Faulkner, Georgine, Kozminski, Wiktor, Svergun, Dmitri I., Warscheid, Bettina, Zagrovic, Bojan, Gautel, Mathias, Konrat, Robert, Djinović-Carugo, Kristina
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8163081/
https://ncbi.nlm.nih.gov/pubmed/34049882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abg7653
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