Structural Insights into Ca(2+)-Calmodulin Regulation of Plectin 1a-Integrin β4 Interaction in Hemidesmosomes

The mechanical stability of epithelial cells, which protect organisms from harmful external factors, is maintained by hemidesmosomes via the interaction between plectin 1a (P1a) and integrin α6β4. Binding of calcium-calmodulin (Ca(2+)-CaM) to P1a together with phosphorylation of integrin β4 disrupts...

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Publicado no:Structure
Main Authors: Song, Jae-Geun, Kostan, Julius, Drepper, Friedel, Knapp, Bettina, de Almeida Ribeiro, Euripedes, Konarev, Petr V., Grishkovskaya, Irina, Wiche, Gerhard, Gregor, Martin, Svergun, Dmitri I., Warscheid, Bettina, Djinović-Carugo, Kristina
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4353693/
https://ncbi.nlm.nih.gov/pubmed/25703379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.01.011
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