Structural Insights into Ca(2+)-Calmodulin Regulation of Plectin 1a-Integrin β4 Interaction in Hemidesmosomes

The mechanical stability of epithelial cells, which protect organisms from harmful external factors, is maintained by hemidesmosomes via the interaction between plectin 1a (P1a) and integrin α6β4. Binding of calcium-calmodulin (Ca(2+)-CaM) to P1a together with phosphorylation of integrin β4 disrupts...

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Bibliografske podrobnosti
izdano v:Structure
Main Authors: Song, Jae-Geun, Kostan, Julius, Drepper, Friedel, Knapp, Bettina, de Almeida Ribeiro, Euripedes, Konarev, Petr V., Grishkovskaya, Irina, Wiche, Gerhard, Gregor, Martin, Svergun, Dmitri I., Warscheid, Bettina, Djinović-Carugo, Kristina
Format: Artigo
Jezik:Inglês
Izdano: Cell Press 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4353693/
https://ncbi.nlm.nih.gov/pubmed/25703379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.01.011
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