IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome

Cytokine release syndrome (CRS) is a life-threatening complication induced by systemic inflammatory responses to infections, including bacteria and chimeric antigen receptor T cell therapy. There are currently no immunotherapies with proven clinical efficacy and understanding of the molecular mechan...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Kang, Sujin, Tanaka, Toshio, Inoue, Hitomi, Ono, Chikako, Hashimoto, Shoji, Kioi, Yoshiyuki, Matsumoto, Hisatake, Matsuura, Hiroshi, Matsubara, Tsunehiro, Shimizu, Kentaro, Ogura, Hiroshi, Matsuura, Yoshiharu, Kishimoto, Tadamitsu
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2020
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7486751/
https://ncbi.nlm.nih.gov/pubmed/32826331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2010229117
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