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FAK promotes early osteoprogenitor cell proliferation by enhancing mTORC1 signaling
Focal adhesion kinase (FAK) has important functions in bone homeostasis but its role in early osteoprogenitor cells is unknown. We show herein that mice lacking FAK in Dermo1-expressing cells exhibited low bone mass and decreased osteoblast number. Mechanistically, FAK-deficient early osteoprogenito...
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| Publicado no: | J Bone Miner Res |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7486225/ https://ncbi.nlm.nih.gov/pubmed/32286710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.4029 |
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