FAK promotes early osteoprogenitor cell proliferation by enhancing mTORC1 signaling

Focal adhesion kinase (FAK) has important functions in bone homeostasis but its role in early osteoprogenitor cells is unknown. We show herein that mice lacking FAK in Dermo1-expressing cells exhibited low bone mass and decreased osteoblast number. Mechanistically, FAK-deficient early osteoprogenito...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Bone Miner Res
Egile Nagusiak: Qi, Shuqun, Sun, Xiumei, Choi, Han Kyoung, Yao, Jinfeng, Wang, Li, Wu, Guomin, He, Yun, Pan, Jian, Guan, Jun-Lin, Liu, Fei
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7486225/
https://ncbi.nlm.nih.gov/pubmed/32286710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.4029
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