Defects in Mitochondrial Biogenesis Drive Mitochondrial Alterations in PARKIN-Deficient Human Dopamine Neurons

Mutations and loss of activity in PARKIN, an E3 ubiquitin ligase, play a role in the pathogenesis of Parkinson's disease (PD). PARKIN regulates many aspects of mitochondrial quality control including mitochondrial autophagy (mitophagy) and mitochondrial biogenesis. Defects in mitophagy have bee...

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Publicat a:Stem Cell Reports
Autors principals: Kumar, Manoj, Acevedo-Cintrón, Jesús, Jhaldiyal, Aanishaa, Wang, Hu, Andrabi, Shaida A., Eacker, Stephen, Karuppagounder, Senthilkumar S., Brahmachari, Saurav, Chen, Rong, Kim, Hyesoo, Ko, Han Seok, Dawson, Valina L., Dawson, Ted M.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7486221/
https://ncbi.nlm.nih.gov/pubmed/32795422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2020.07.013
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