Enhanced Characterization of Drug Metabolism and the Influence of the Intestinal Microbiome: A Pharmacokinetic, Microbiome, and Untargeted Metabolomics Study

Determining factors that contribute to interindividual and intra‐individual variability in pharmacokinetics (PKs) and drug metabolism is essential for the optimal use of drugs in humans. Intestinal microbes are important contributors to variability; however, such gut microbe‐drug interactions and th...

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Publicado en:Clin Transl Sci
Main Authors: Jarmusch, Alan K., Vrbanac, Alison, Momper, Jeremiah D., Ma, Joseph D., Alhaja, Maher, Liyanage, Marlon, Knight, Rob, Dorrestein, Pieter C., Tsunoda, Shirley M.
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2020
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7485946/
https://ncbi.nlm.nih.gov/pubmed/32216086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12785
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