MicroRNA expression profiles in molecular subtypes of clear-cell renal cell carcinoma are associated with clinical outcome and repression of specific mRNA targets

Clear-cell renal cell carcinomas (ccRCC) can be divided into four transcriptomic subtypes, two of which have a favorable and two an unfavorable prognosis. To assess mechanisms driving these subtypes, we investigated their miRNA expression patterns. miRNAs are master regulators of mRNAs, that are wid...

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Vydáno v:PLoS One
Hlavní autoři: Verbiest, Annelies, Van Hoef, Vincent, Rodriguez-Antona, Cristina, García-Donas, Jesús, Graña-Castro, Osvaldo, Albersen, Maarten, Baldewijns, Marcella, Laenen, Annouschka, Roussel, Eduard, Schöffski, Patrick, Wozniak, Agnieszka, Caruso, Stefano, Couchy, Gabrielle, Zucman-Rossi, Jessica, Beuselinck, Benoit
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7485767/
https://ncbi.nlm.nih.gov/pubmed/32915890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0238809
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