MicroRNAs Targeting HIF-2α, VEGFR1 and/or VEGFR2 as Potential Predictive Biomarkers for VEGFR Tyrosine Kinase and HIF-2α Inhibitors in Metastatic Clear-Cell Renal Cell Carcinoma

SIMPLE SUMMARY: Metastatic clear-cell renal cell carcinoma is characterized by heightened angiogenesis through increased expression of HIF-2α and VEGFR2. VEGFR tyrosine kinase inhibitors are a cornerstone of metastatic clear-cell renal cell carcinoma treatment, and new treatments targeting HIF-2α ar...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Kinget, Lisa, Roussel, Eduard, Verbiest, Annelies, Albersen, Maarten, Rodríguez-Antona, Cristina, Graña-Castro, Osvaldo, Inglada-Pérez, Lucía, Zucman-Rossi, Jessica, Couchy, Gabrielle, Job, Sylvie, de Reyniès, Aurélien, Laenen, Annouschka, Baldewijns, Marcella, Beuselinck, Benoit
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8235409/
https://ncbi.nlm.nih.gov/pubmed/34205829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13123099
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