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Organic Solvents for Enhanced Proteolysis of Stable Proteins for Hydrogen/Deuterium Exchange Mass Spectrometry
Protein digestion is a key challenge in mass spectrometry (MS)-based structural proteomics. Although using hydrogen deuterium exchange kinetics with mass spectrometry (HDX-MS) to interrogate high order structure of proteins is now established, it can be challenging for ß-barrel proteins, which are i...
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| 發表在: | Anal Chem |
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| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7485609/ https://ncbi.nlm.nih.gov/pubmed/32867496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.0c02194 |
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