The synthetic small molecule FL3 combats intestinal tumorigenesis via Axin1-mediated inhibition of Wnt/beta-catenin signaling

Colorectal cancer (CRC) exhibits aberrant activation of Wnt/beta-catenin signaling. Many inhibitors of the Wnt/beta-catenin pathway have been tested for Wnt-dependent cancers including CRC but are unsuccessful due to severe adverse reactions. FL3 is a synthetic derivative of natural products called...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Cancer Res
Main Authors: Jackson, Dakota N., Alula, Kibrom M., Delgado-Deida, Yaritza, Tabti, Redouane, Turner, Kevin, Wang, Xuan, Venuprasad, K., Souza, Rhonda F, Désaubry, Laurent, Theiss, Arianne L.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484901/
https://ncbi.nlm.nih.gov/pubmed/32665357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-0216
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares