Mechanism of action of SNF472, a novel calcification inhibitor to treat vascular calcification and calciphylaxis

BACKGROUND AND PURPOSE: No therapy is approved for vascular calcification or calcific uraemic arteriolopathy (calciphylaxis), which increases mortality and morbidity in patients undergoing dialysis. Deposition of hydroxyapatite (HAP) crystals in arterial walls is the common pathophysiologic mechanis...

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Bibliografiske detaljer
Udgivet i:Br J Pharmacol
Main Authors: Perelló, Joan, Ferrer, Miquel D., del Mar Pérez, Maria, Kaesler, Nadine, Brandenburg, Vincent M., Behets, Geert J., D'Haese, Patrick C., Garg, Rekha, Isern, Bernat, Gold, Alex, Wolf, Myles, Salcedo, Carolina
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484563/
https://ncbi.nlm.nih.gov/pubmed/32557649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15163
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