Mechanism of action of SNF472, a novel calcification inhibitor to treat vascular calcification and calciphylaxis

BACKGROUND AND PURPOSE: No therapy is approved for vascular calcification or calcific uraemic arteriolopathy (calciphylaxis), which increases mortality and morbidity in patients undergoing dialysis. Deposition of hydroxyapatite (HAP) crystals in arterial walls is the common pathophysiologic mechanis...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Perelló, Joan, Ferrer, Miquel D., del Mar Pérez, Maria, Kaesler, Nadine, Brandenburg, Vincent M., Behets, Geert J., D'Haese, Patrick C., Garg, Rekha, Isern, Bernat, Gold, Alex, Wolf, Myles, Salcedo, Carolina
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484563/
https://ncbi.nlm.nih.gov/pubmed/32557649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15163
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