Inhibition of Bruton's TK regulates macrophage NF‐κB and NLRP3 inflammasome activation in metabolic inflammation

BACKGROUND AND PURPOSE: There are no medications currently available to treat metabolic inflammation. Bruton's tyrosine kinase (BTK) is highly expressed in monocytes and macrophages and regulates NF‐κB and NLRP3 inflammasome activity; both propagate metabolic inflammation in diet‐induced obesit...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Purvis, Gareth S.D., Collino, Massimo, Aranda‐Tavio, Haidee, Chiazza, Fausto, O'Riordan, Caroline E., Zeboudj, Lynda, Mohammad, Shireen, Collotta, Debora, Verta, Roberta, Guisot, Nicolas E.S., Bunyard, Peter, Yaqoob, Magdi M., Greaves, David R., Thiemermann, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484557/
https://ncbi.nlm.nih.gov/pubmed/32608058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15182
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