Epigenetic silencing of the ubiquitin ligase subunit FBXL7 impairs c-SRC degradation and promotes epithelial-to-mesenchymal transition and metastasis

Epigenetic plasticity is a pivotal factor driving metastasis. Here, we show that the promoter of the gene encoding the ubiquitin ligase subunit FBXL7 is hypermethylated in advanced prostate and pancreatic cancers, correlating with decreased FBXL7 mRNA and protein levels. Low FBXL7 mRNA levels are pr...

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Pubblicato in:Nat Cell Biol
Autori principali: Moro, Loredana, Simoneschi, Daniele, Kurz, Emma, Arbini, Arnaldo A., Jang, Shaowen, Guaragnella, Nicoletta, Giannattasio, Sergio, Wang, Wei, Chen, Yu-An, Pires, Geoffrey, Dang, Andrew, Hernandez, Elizabeth, Kapur, Payal, Mishra, Ankita, Tsirigos, Aristotelis, Miller, George, Hsieh, Jer-Tsong, Pagano, Michele
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484425/
https://ncbi.nlm.nih.gov/pubmed/32839549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-020-0560-6
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