Epigenetic silencing of the ubiquitin ligase subunit FBXL7 impairs c-SRC degradation and promotes epithelial-to-mesenchymal transition and metastasis

Epigenetic plasticity is a pivotal factor driving metastasis. Here, we show that the promoter of the gene encoding the ubiquitin ligase subunit FBXL7 is hypermethylated in advanced prostate and pancreatic cancers, correlating with decreased FBXL7 mRNA and protein levels. Low FBXL7 mRNA levels are pr...

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Publicado no:Nat Cell Biol
Main Authors: Moro, Loredana, Simoneschi, Daniele, Kurz, Emma, Arbini, Arnaldo A., Jang, Shaowen, Guaragnella, Nicoletta, Giannattasio, Sergio, Wang, Wei, Chen, Yu-An, Pires, Geoffrey, Dang, Andrew, Hernandez, Elizabeth, Kapur, Payal, Mishra, Ankita, Tsirigos, Aristotelis, Miller, George, Hsieh, Jer-Tsong, Pagano, Michele
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484425/
https://ncbi.nlm.nih.gov/pubmed/32839549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-020-0560-6
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