Epigenetic silencing of the ubiquitin ligase subunit FBXL7 impairs c-SRC degradation and promotes epithelial-to-mesenchymal transition and metastasis

Epigenetic plasticity is a pivotal factor driving metastasis. Here, we show that the promoter of the gene encoding the ubiquitin ligase subunit FBXL7 is hypermethylated in advanced prostate and pancreatic cancers, correlating with decreased FBXL7 mRNA and protein levels. Low FBXL7 mRNA levels are pr...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Nat Cell Biol
Päätekijät: Moro, Loredana, Simoneschi, Daniele, Kurz, Emma, Arbini, Arnaldo A., Jang, Shaowen, Guaragnella, Nicoletta, Giannattasio, Sergio, Wang, Wei, Chen, Yu-An, Pires, Geoffrey, Dang, Andrew, Hernandez, Elizabeth, Kapur, Payal, Mishra, Ankita, Tsirigos, Aristotelis, Miller, George, Hsieh, Jer-Tsong, Pagano, Michele
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2020
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484425/
https://ncbi.nlm.nih.gov/pubmed/32839549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-020-0560-6
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