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6-Thioguanine and Its Analogs Promote Apoptosis of Castration-Resistant Prostate Cancer Cells in a BRCA2-Dependent Manner

Background: Mutations in the oncosuppressor gene BReast CAncer susceptibility gene 2 (BRCA2) predispose to aggressive forms of prostate cancer which show poor response to taxane-based therapy, the standard treatment for castration-resistant, aggressive prostate cancer. Herein, we addressed the quest...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Laera, Luna, Guaragnella, Nicoletta, Giannattasio, Sergio, Moro, Loredana
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6678799/
https://ncbi.nlm.nih.gov/pubmed/31284411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11070945
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