Single Cell Transcriptomic Profiling of Vascular Smooth Muscle Cell Phenotype Modulation in Marfan Syndrome Aortic Aneurysm

OBJECTIVE: To delineate temporal and spatial dynamics of vascular smooth muscle (SMC) transcriptomic changes during aortic aneurysm development in Marfan syndrome (MFS). APPROACH AND RESULTS: We performed single-cell RNA sequencing (scRNAseq) to study aortic root/ascending aneurysm tissue from Fbn1(...

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Pubblicato in:Arterioscler Thromb Vasc Biol
Autori principali: Pedroza, Albert J., Tashima, Yasushi, Shad, Rohan, Cheng, Paul, Wirka, Robert, Churovich, Samantha, Nakamura, Ken, Yokoyama, Nobu, Cui, Jason Z., Iosef, Cristiana, Hiesinger, William, Quertermous, Thomas, Fischbein, Michael P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484233/
https://ncbi.nlm.nih.gov/pubmed/32698686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.120.314670
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