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2-Hydroxypropyl-β-cyclodextrin ototoxicity in adult rats: rapid onset and massive destruction of both inner and outer hair cells above a critical dose
2-hydroxypropyl-β-cyclodextrin (HPβCD), a cholesterol chelator, is being used to treat diseases associated with abnormal cholesterol metabolism such as Niemann-Pick C1 (NPC1) However, the high doses of HPβCD needed to slow disease progression may cause hearing loss. Previous studies in mice have sug...
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| Publicat a: | Neurotox Res |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7484207/ https://ncbi.nlm.nih.gov/pubmed/32607920 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12640-020-00252-7 |
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