Spatiotemporal Developmental Upregulation of Prestin Correlates With the Severity and Location of Cyclodextrin-Induced Outer Hair Cell Loss and Hearing Loss

2-Hyroxypropyl-beta-cyclodextrin (HPβCD) is being used to treat Niemann-Pick C1, a fatal neurodegenerative disease caused by abnormal cholesterol metabolism. HPβCD slows disease progression, but unfortunately causes severe, rapid onset hearing loss by destroying the outer hair cells (OHC). HPβCD-ind...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Ding, Dalian, Jiang, Haiyan, Manohar, Senthilvelan, Liu, Xiaopeng, Li, Li, Chen, Guang-Di, Salvi, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8181405/
https://ncbi.nlm.nih.gov/pubmed/34109172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.643709
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