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2-Hydroxypropyl-β-cyclodextrin ototoxicity in adult rats: rapid onset and massive destruction of both inner and outer hair cells above a critical dose
2-hydroxypropyl-β-cyclodextrin (HPβCD), a cholesterol chelator, is being used to treat diseases associated with abnormal cholesterol metabolism such as Niemann-Pick C1 (NPC1) However, the high doses of HPβCD needed to slow disease progression may cause hearing loss. Previous studies in mice have sug...
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| Veröffentlicht in: | Neurotox Res |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7484207/ https://ncbi.nlm.nih.gov/pubmed/32607920 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12640-020-00252-7 |
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