Epigenetic regulation of DNA repair pathway choice by macroH2A1 splice variants ensures genome stability

The inactive X chromosome (Xi) is inherently susceptible to genomic aberrations. Replication stress (RS) has been proposed as an underlying cause, but the mechanisms that protect from Xi instability remain unknown. Here, we show that macroH2A1.2—an RS-protective histone variant enriched on the Xi—is...

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Veröffentlicht in:Mol Cell
Hauptverfasser: Sebastian, Robin, Hosogane, Eri K., Sun, Eric G., Tran, Andy D., Reinhold, William C., Burkett, Sandra, Sturgill, David M., Gudla, Prabhakar R., Pommier, Yves, Aladjem, Mirit I., Oberdoerffer, Philipp
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483679/
https://ncbi.nlm.nih.gov/pubmed/32649884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.06.028
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