Epigenetic regulation of DNA repair pathway choice by macroH2A1 splice variants ensures genome stability

The inactive X chromosome (Xi) is inherently susceptible to genomic aberrations. Replication stress (RS) has been proposed as an underlying cause, but the mechanisms that protect from Xi instability remain unknown. Here, we show that macroH2A1.2—an RS-protective histone variant enriched on the Xi—is...

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Publicado no:Mol Cell
Main Authors: Sebastian, Robin, Hosogane, Eri K., Sun, Eric G., Tran, Andy D., Reinhold, William C., Burkett, Sandra, Sturgill, David M., Gudla, Prabhakar R., Pommier, Yves, Aladjem, Mirit I., Oberdoerffer, Philipp
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483679/
https://ncbi.nlm.nih.gov/pubmed/32649884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.06.028
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