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Cryo-EM of elongating ribosome with EF-Tu•GTP elucidates tRNA proofreading
Ribosomes accurately decode mRNA by proofreading each aminoacyl-tRNA delivered by elongation factor EF-Tu(1). Understanding the molecular mechanism of proofreading requires visualizing GTP-catalyzed elongation, which has remained a challenge(2–4). Here, time-resolved cryo-EM revealed 33 states follo...
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| Publié dans: | Nature |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7483604/ https://ncbi.nlm.nih.gov/pubmed/32612237 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2447-x |
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