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Low-Frequency Intrapulmonary Percussive Ventilation Increases Aerosol Penetration in a 2-Compartment Physical Model of Fibrotic Lung Disease

In patients with fibrotic pulmonary disease such as idiopathic pulmonary fibrosis (IPF), inhaled aerosols deposit mostly in the less affected region of the lungs, resulting in suboptimal pharmacokinetics of airway-delivered treatments. Refinement of aerosol delivery technique requires new models to...

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Foilsithe in:Front Bioeng Biotechnol
Main Authors: Le Guellec, Sandrine, Allimonnier, Laurine, Heuzé-Vourc’h, Nathalie, Cabrera, Maria, Ossant, Frédéric, Pourchez, Jérémie, Vecellio, Laurent, Plantier, Laurent
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483496/
https://ncbi.nlm.nih.gov/pubmed/32984287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2020.01022
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