Low-Frequency Intrapulmonary Percussive Ventilation Increases Aerosol Penetration in a 2-Compartment Physical Model of Fibrotic Lung Disease

In patients with fibrotic pulmonary disease such as idiopathic pulmonary fibrosis (IPF), inhaled aerosols deposit mostly in the less affected region of the lungs, resulting in suboptimal pharmacokinetics of airway-delivered treatments. Refinement of aerosol delivery technique requires new models to...

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Dades bibliogràfiques
Publicat a:Front Bioeng Biotechnol
Autors principals: Le Guellec, Sandrine, Allimonnier, Laurine, Heuzé-Vourc’h, Nathalie, Cabrera, Maria, Ossant, Frédéric, Pourchez, Jérémie, Vecellio, Laurent, Plantier, Laurent
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Bioengineering and Biotechnology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483496/
https://ncbi.nlm.nih.gov/pubmed/32984287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2020.01022
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