MEF2C hypofunction in neuronal and neuroimmune populations produces MEF2C haploinsufficiency syndrome-like behaviors in mice

BACKGROUND: Microdeletions of the MEF2C gene are linked to a syndromic form of autism termed MEF2C Haploinsufficiency Syndrome (MCHS). MEF2C hypofunction in neurons is presumed to underlie most of the MCHS symptoms. However, it is unclear in which cell populations MEF2C functions to regulate neuroty...

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Xehetasun bibliografikoak
Argitaratua izan da:Biol Psychiatry
Egile Nagusiak: Harrington, Adam J., Bridges, Catherine M., Berto, Stefano, Blankenship, Kayla, Cho, Jennifer Y., Assali, Ahlem, Siemsen, Benjamin M., Moore, Hannah W., Tsvetkov, Evgeny, Thielking, Acadia, Konopka, Genevieve, Everman, David B., Scofield, Michael D., Skinner, Steven A., Cowan, Christopher W.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483399/
https://ncbi.nlm.nih.gov/pubmed/32418612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2020.03.011
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