MEF2C hypofunction in neuronal and neuroimmune populations produces MEF2C haploinsufficiency syndrome-like behaviors in mice

BACKGROUND: Microdeletions of the MEF2C gene are linked to a syndromic form of autism termed MEF2C Haploinsufficiency Syndrome (MCHS). MEF2C hypofunction in neurons is presumed to underlie most of the MCHS symptoms. However, it is unclear in which cell populations MEF2C functions to regulate neuroty...

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Veröffentlicht in:Biol Psychiatry
Hauptverfasser: Harrington, Adam J., Bridges, Catherine M., Berto, Stefano, Blankenship, Kayla, Cho, Jennifer Y., Assali, Ahlem, Siemsen, Benjamin M., Moore, Hannah W., Tsvetkov, Evgeny, Thielking, Acadia, Konopka, Genevieve, Everman, David B., Scofield, Michael D., Skinner, Steven A., Cowan, Christopher W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483399/
https://ncbi.nlm.nih.gov/pubmed/32418612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2020.03.011
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