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Photo-Click-Facilitated Screening Platform for the Development of Hetero-Bivalent Agents with High Potency

A novel photo-click-based platform has been developed for rapid screening and affinity optimization of heterobivalent agents. This method allows for the efficient selection of high-affinity dual receptor-targeting agents via streamlining tedious organic synthesis and biological evaluation procedures...

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Detalhes bibliográficos
Publicado no:J Org Chem
Main Authors: Sun, Lingyi, Gai, Yongkang, McNitt, Christopher D., Sun, Jun, Zhang, Xiaohui, Xing, Wei, Li, Zhonghan, Popik, Vladimir V., Zeng, Dexing
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483003/
https://ncbi.nlm.nih.gov/pubmed/32223160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.9b03122
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