The Polygenic and Monogenic Basis of Blood Traits and Diseases

Blood cells play essential roles in human health, underpinning physiological processes such as immunity, oxygen transport, and clotting, which when perturbed cause a significant global health burden. Here we integrate data from UK Biobank and a large-scale international collaborative effort, includi...

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Veröffentlicht in:Cell
Hauptverfasser: Vuckovic, Dragana, Bao, Erik L., Akbari, Parsa, Lareau, Caleb A., Mousas, Abdou, Jiang, Tao, Chen, Ming-Huei, Raffield, Laura M., Tardaguila, Manuel, Huffman, Jennifer E., Ritchie, Scott C., Megy, Karyn, Ponstingl, Hannes, Penkett, Christopher J., Albers, Patrick K., Wigdor, Emilie M., Sakaue, Saori, Moscati, Arden, Manansala, Regina, Lo, Ken Sin, Qian, Huijun, Akiyama, Masato, Bartz, Traci M., Ben-Shlomo, Yoav, Beswick, Andrew, Bork-Jensen, Jette, Bottinger, Erwin P., Brody, Jennifer A., van Rooij, Frank J.A., Chitrala, Kumaraswamy N., Wilson, Peter W.F., Choquet, Hélène, Danesh, John, Di Angelantonio, Emanuele, Dimou, Niki, Ding, Jingzhong, Elliott, Paul, Esko, Tõnu, Evans, Michele K., Felix, Stephan B., Floyd, James S., Broer, Linda, Grarup, Niels, Guo, Michael H., Guo, Qi, Greinacher, Andreas, Haessler, Jeff, Hansen, Torben, Howson, Joanna M.M., Huang, Wei, Jorgenson, Eric, Kacprowski, Tim, Kähönen, Mika, Kamatani, Yoichiro, Kanai, Masahiro, Karthikeyan, Savita, Koskeridis, Fotios, Lange, Leslie A., Lehtimäki, Terho, Linneberg, Allan, Liu, Yongmei, Lyytikäinen, Leo-Pekka, Manichaikul, Ani, Matsuda, Koichi, Mohlke, Karen L., Mononen, Nina, Murakami, Yoshinori, Nadkarni, Girish N., Nikus, Kjell, Pankratz, Nathan, Pedersen, Oluf, Preuss, Michael, Psaty, Bruce M., Raitakari, Olli T., Rich, Stephen S., Rodriguez, Benjamin A.T., Rosen, Jonathan D., Rotter, Jerome I., Schubert, Petra, Spracklen, Cassandra N., Surendran, Praveen, Tang, Hua, Tardif, Jean-Claude, Ghanbari, Mohsen, Völker, Uwe, Völzke, Henry, Watkins, Nicholas A., Weiss, Stefan, Cai, Na, Kundu, Kousik, Watt, Stephen B., Walter, Klaudia, Zonderman, Alan B., Cho, Kelly, Li, Yun, Loos, Ruth J.F., Knight, Julian C., Georges, Michel, Stegle, Oliver, Evangelou, Evangelos, Okada, Yukinori, Roberts, David J., Inouye, Michael, Johnson, Andrew D., Auer, Paul L., Astle, William J., Reiner, Alexander P., Butterworth, Adam S., Ouwehand, Willem H., Lettre, Guillaume, Sankaran, Vijay G., Soranzo, Nicole
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7482360/
https://ncbi.nlm.nih.gov/pubmed/32888494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.08.008
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