Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations

Most loci identified by GWAS have been found in populations of European ancestry (EUR). In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including 184,535 non-EUR individuals, we identified 5,552 trait-variant associations at P<5×10(−9), including 71 novel loci n...

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Vydáno v:Cell
Hlavní autoři: Chen, Ming-Huei, Raffield, Laura M., Mousas, Abdou, Sakaue, Saori, Huffman, Jennifer E., Moscati, Arden, Trivedi, Bhavi, Jiang, Tao, Akbari, Parsa, Vuckovic, Dragana, Bao, Erik L., Zhong, Xue, Manansala, Regina, Laplante, Véronique, Chen, Minhui, Lo, Ken Sin, Qian, Huijun, Lareau, Caleb A., Beaudoin, Mélissa, Hunt, Karen A., Akiyama, Masato, Bartz, Traci M., Ben-Shlomo, Yoav, Beswick, Andrew, Bork-Jensen, Jette, Bottinger, Erwin P., Brody, Jennifer A., van Rooij, Frank J.A., Chitrala, Kumaraswamynaidu, Cho, Kelly, Choquet, Hélène, Correa, Adolfo, Danesh, John, Angelantonio, Emanuele Di, Dimou, Niki, Ding, Jingzhong, Elliott, Paul, Esko, Tõnu, Evans, Michele K., Floyd, James S., Broer, Linda, Grarup, Niels, Guo, Michael H., Greinacher, Andreas, Haessler, Jeff, Hansen, Torben, Howson, Joanna M. M., Huang, Qin Qin, Huang, Wei, Jorgenson, Eric, Kacprowski, Tim, Kähönen, Mika, Kamatani, Yoichiro, Kanai, Masahiro, Karthikeyan, Savita, Koskeridis, Fotis, Lange, Leslie A., Lehtimäki, Terho, Lerch, Markus M., Linneberg, Allan, Liu, Yongmei, Lyytikäinen, Leo-Pekka, Manichaikul, Ani, Martin, Hilary C., Matsuda, Koichi, Mohlke, Karen L., Mononen, Nina, Murakami, Yoshinori, Nadkarni, Girish N., Nauck, Matthias, Nikus, Kjell, Ouwehand, Willem H., Pankratz, Nathan, Pedersen, Oluf, Preuss, Michael, Psaty, Bruce M., Raitakari, Olli T., Roberts, David J., Rich, Stephen S., Rodriguez, Benjamin A.T., Rosen, Jonathan D., Rotter, Jerome I., Schubert, Petra, Spracklen, Cassandra N., Surendran, Praveen, Tang, Hua, Tardif, Jean-Claude, Trembath, Richard C., Ghanbari, Mohsen, Völker, Uwe, Völzke, Henry, Watkins, Nicholas A., Zonderman, Alan B., Wilson, Peter W.F., Li, Yun, Butterworth, Adam S., Gauchat, Jean-François, Chiang, Charleston W.K., Li, Bingshan, Loos, Ruth J.F., Astle, William J., Evangelou, Evangelos, van Heel, David A., Sankaran, Vijay G., Okada, Yukinori, Soranzo, Nicole, Johnson, Andrew D., Reiner, Alexander P., Auer, Paul L., Lettre, Guillaume
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7480402/
https://ncbi.nlm.nih.gov/pubmed/32888493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.06.045
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