Phospho-Proteomic Discovery of Novel EPO Signal Transducers Including TXNIP as a Mediator of EPO- Dependent Human Erythropoiesis

Erythroid cell formation critically depends upon signals transduced via EPO/EPOR/JAK2 complexes. This includes not only core response modules (e.g., JAK2/STAT5, RAS/MEK/ERK), but also specialized effectors (e.g., Erythroferrone, ASCT2 glutamine transport, Spi2A). By employing phospho-proteomics and...

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Udgivet i:Exp Hematol
Main Authors: Held, Matthew A., Greenfest-Allen, Emily, Jachimowicz, Edward, Stoeckert, Christian J., Stokes, Matthew P., Wood, Antony W., Wojchowski, Don M.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7480993/
https://ncbi.nlm.nih.gov/pubmed/32259549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2020.03.003
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