Genomic Profiling Identified ERCC2 E606Q Mutation in Helicase Domain Respond to Platinum-Based Neoadjuvant Therapy in Urothelial Bladder Cancer

Genomic profiling of tumors enables therapeutic decisions, and identifying drug-matched mutations will prolong survival and prognosis. Here, we generated a custom panel for detecting genetic alterations in 19 patients with urothelial bladder cancer. This panel targeted 71 genes associated with urolo...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Hirotsu, Yosuke, Yokoyama, Hitoshi, Amemiya, Kenji, Hagimoto, Takashi, Hosaka, Kyoko, Oyama, Toshio, Mochizuki, Hitoshi, Omata, Masao
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7480179/
https://ncbi.nlm.nih.gov/pubmed/32984035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.01643
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