Accurate detection of KRAS, NRAS and BRAF mutations in metastatic colorectal cancers by bridged nucleic acid-clamp real-time PCR

BACKGROUND: Patients with metastatic colorectal cancer can benefit from anti-EGFR therapy, such as cetuximab and panitumumab. However, colorectal cancers harboring constitutive activating mutations in KRAS, NRAS and BRAF genes are not responsive to anti-EGFR therapy. To select patients for appropria...

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Enregistré dans:
Détails bibliographiques
Publié dans:BMC Med Genomics
Auteurs principaux: Nagakubo, Yuki, Hirotsu, Yosuke, Amemiya, Kenji, Oyama, Toshio, Mochizuki, Hitoshi, Omata, Masao
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2019
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6849194/
https://ncbi.nlm.nih.gov/pubmed/31711486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-019-0610-8
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