Deglycosylated Azithromycin Targets Transgelin to Enhance Intestinal Smooth Muscle Function

Azithromycin (AZM) has been widely used as an antibacterial drug for many years. It has also been used to treat delayed gastric emptying. However, it exerts several side effects. We found that deglycosylated AZM (Deg-AZM or CP0119), an AZM metabolite, is a positively strong intestinal agonist that m...

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Publicado no:iScience
Main Authors: Zhong, Weilong, Sun, Bo, Ruan, Hao, Yang, Guang, Qian, Baoxin, Cao, Hailong, He, Lingfei, Fan, Yunjing, Roberts, Arthur G., Liu, Xiang, Hu, Xuejiao, Liang, Yuan, Ye, Qing, Yin, Tingting, Wang, Bangmao, Yang, Cheng, Sun, Tao, Zhou, Honggang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7479357/
https://ncbi.nlm.nih.gov/pubmed/32889431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101464
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