An [(18)F]-positron emitting fluorophore allows safe evaluation of small molecule distribution in the CSF, CSF fistulas, and CNS device placement

The small molecule fluorescein is commonly used to guide the repair of cerebral spinal fluid leaks (CSFLs) in the clinic. We modified fluorescein so that it is also visible by positron emission tomography (PET). This probe was used to quantitatively track the fast distribution of small molecules in...

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Bibliografiske detaljer
Udgivet i:Mol Pharm
Main Authors: Guo, Hua, Kommidi, Harikrishna, Maachani, Uday B., Voronina, Julia C., Zhang, Weiqi, Magge, Rajiv S., Ivanidze, Jana, Wu, Amy P., Souweidane, Mark M., Aras, Omer, Ting, Richard
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7478905/
https://ncbi.nlm.nih.gov/pubmed/31290330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.9b00485
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