Uptake of exogenous serine is important to maintain sphingolipid homeostasis in Saccharomyces cerevisiae

Sphingolipids are abundant and essential molecules in eukaryotes that have crucial functions as signaling molecules and as membrane components. Sphingolipid biosynthesis starts in the endoplasmic reticulum with the condensation of serine and palmitoyl-CoA. Sphingolipid biosynthesis is highly regulat...

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Udgivet i:PLoS Genet
Main Authors: Esch, Bianca M., Limar, Sergej, Bogdanowski, André, Gournas, Christos, More, Tushar, Sundag, Celine, Walter, Stefan, Heinisch, Jürgen J., Ejsing, Christer S., André, Bruno, Fröhlich, Florian
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7478846/
https://ncbi.nlm.nih.gov/pubmed/32845888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008745
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