Blueprint of human thymopoiesis reveals molecular mechanisms of stage-specific TCR enhancer activation

Cell differentiation is accompanied by epigenetic changes leading to precise lineage definition and cell identity. Here we present a comprehensive resource of epigenomic data of human T cell precursors along with an integrative analysis of other hematopoietic populations. Although T cell commitment...

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Udgivet i:J Exp Med
Main Authors: Cieslak, Agata, Charbonnier, Guillaume, Tesio, Melania, Mathieu, Eve-Lyne, Belhocine, Mohamed, Touzart, Aurore, Smith, Charlotte, Hypolite, Guillaume, Andrieu, Guillaume P., Martens, Joost H.A., Janssen-Megens, Eva, Gut, Marta, Gut, Ivo, Boissel, Nicolas, Petit, Arnaud, Puthier, Denis, Macintyre, Elizabeth, Stunnenberg, Hendrik G., Spicuglia, Salvatore, Asnafi, Vahid
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7478722/
https://ncbi.nlm.nih.gov/pubmed/32667968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20192360
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