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Cathepsin K Is a Potent Disaggregase of α-Synuclein Fibrils
The intracellular accumulation of α-synuclein (α-syn) amyloid fibrils is a hallmark of Parkinson’s disease. Because lysosomes are responsible for degrading aggregated species, enhancing lysosomal function could alleviate the overburden of α-syn. Previously, we showed that cysteine cathepsins (Cts) i...
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| Publié dans: | Biochem Biophys Res Commun |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7478362/ https://ncbi.nlm.nih.gov/pubmed/32819572 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2020.06.155 |
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