Cutting Edge: Inhibition of Glycogen Synthase Kinase 3 Activity Induces the Generation and Enhanced Suppressive Function of Human IL-10(+) FOXP3(+)–Induced Regulatory T Cells

IL-10 is critical for Foxp3(+) regulatory T cell (Tregs)–mediated immune suppression, but how to efficiently upregulate IL-10 production in Tregs remains unclear. In this article, we show that human IL-10(+) FOXP3(+)–induced regulatory T cell (iTreg) generation can be dramatically promoted by inhibi...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Immunol
Auteurs principaux: Cheng, Hao, Wang, Lingbiao, Yang, Biaolong, Li, Dan, Wang, Xiaoxia, Liu, Xinnan, Tian, Na, Huang, Qianru, Feng, Ru, Wang, Zhengting, Liang, Rui, Dai, Sheng-Ming, Lv, Ling, Wu, Ji, Zang, Yuan-Sheng, Li, Bin
Format: Artigo
Langue:Inglês
Publié: AAI 2020
Sujets:
Cutting Edge
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7477744/
https://ncbi.nlm.nih.gov/pubmed/32817370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2000136
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