Targeting all transforming growth factor-β isoforms with an Fc chimeric receptor impairs tumor growth and angiogenesis of oral squamous cell cancer

Tumor progression is governed by various growth factors and cytokines in the tumor microenvironment (TME). Among these, transforming growth factor-β (TGF-β) is secreted by various cell types residing in the TME and promotes tumor progression by inducing the epithelial-to-mesenchymal transition (EMT)...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Takahashi, Kazuki, Akatsu, Yuichi, Podyma-Inoue, Katarzyna A., Matsumoto, Takehisa, Takahashi, Hitomi, Yoshimatsu, Yasuhiro, Koinuma, Daizo, Shirouzu, Mikako, Miyazono, Kohei, Watabe, Tetsuro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7476713/
https://ncbi.nlm.nih.gov/pubmed/32631954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012492
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