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Targeting all transforming growth factor-β isoforms with an Fc chimeric receptor impairs tumor growth and angiogenesis of oral squamous cell cancer

Tumor progression is governed by various growth factors and cytokines in the tumor microenvironment (TME). Among these, transforming growth factor-β (TGF-β) is secreted by various cell types residing in the TME and promotes tumor progression by inducing the epithelial-to-mesenchymal transition (EMT)...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Takahashi, Kazuki, Akatsu, Yuichi, Podyma-Inoue, Katarzyna A., Matsumoto, Takehisa, Takahashi, Hitomi, Yoshimatsu, Yasuhiro, Koinuma, Daizo, Shirouzu, Mikako, Miyazono, Kohei, Watabe, Tetsuro
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7476713/
https://ncbi.nlm.nih.gov/pubmed/32631954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012492
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