Targeting all transforming growth factor-β isoforms with an Fc chimeric receptor impairs tumor growth and angiogenesis of oral squamous cell cancer

Tumor progression is governed by various growth factors and cytokines in the tumor microenvironment (TME). Among these, transforming growth factor-β (TGF-β) is secreted by various cell types residing in the TME and promotes tumor progression by inducing the epithelial-to-mesenchymal transition (EMT)...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Takahashi, Kazuki, Akatsu, Yuichi, Podyma-Inoue, Katarzyna A., Matsumoto, Takehisa, Takahashi, Hitomi, Yoshimatsu, Yasuhiro, Koinuma, Daizo, Shirouzu, Mikako, Miyazono, Kohei, Watabe, Tetsuro
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7476713/
https://ncbi.nlm.nih.gov/pubmed/32631954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012492
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