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Yeast ATM and ATR kinases use different mechanisms to spread histone H2A phosphorylation around a DNA double-strand break

One of the hallmarks of DNA damage is the rapid spreading of phosphorylated histone H2A (γ-H2AX) around a DNA double-strand break (DSB). In the budding yeast Saccharomyces cerevisiae, nearly all H2A isoforms can be phosphorylated, either by Mec1(ATR) or Tel1(ATM) checkpoint kinases. We induced a sit...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Li, Kevin, Bronk, Gabriel, Kondev, Jane, Haber, James E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7474660/
https://ncbi.nlm.nih.gov/pubmed/32817543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2002126117
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