IL-12 p40 monomer is different from other IL-12 family members to selectively inhibit IL-12Rβ1 internalization and suppress EAE

Multiple sclerosis (MS) is the most common human demyelinating disease of the central nervous system. The IL-12 family of cytokines has four members, which are IL-12 (p40:p35), IL-23 (p40:p19), the p40 monomer (p40), and the p40 homodimer (p40(2)). Since all four members contain p40 in different for...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Mondal, Susanta, Kundu, Madhuchhanda, Jana, Malabendu, Roy, Avik, Rangasamy, Suresh B., Modi, Khushbu K., Wallace, Jennillee, Albalawi, Yasmeen A., Balabanov, Roumen, Pahan, Kalipada
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2020
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7474649/
https://ncbi.nlm.nih.gov/pubmed/32817415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2000653117
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